Grandstaff Canyon includes a perennial stream within a canyon bordered by sheer walls of Navajo sandstone. Morning Glory Natural Bridge, located just outside of the WSA on State Land, is the main destination for hikers. A ribbon of riparian vegetation follows the stream within the canyon. Above the canyon, there is a sparse covering of pinyon-juniper vegetation and large expanses of barren Navajo sandstone domes and fins.

Negro Bill Canyon WSA is located northeast of Moab. The mouth of Grandstaff Canyon is accessible from Utah State Highway 128. The Sand Flats Road provides access to the upper portion of the WSA.