Travelling south on highway 395 or east/west on highway 299: Travel south down main street/highway 395 until you are nearly out of town. Take a left on County Road 56. Travel approximately 1 mile before turning right onto County Road 115. After 1.5 miles turn left onto the Modoc NWR main entrance road.
Travelling north on highway 395: After passing through the town of Likely, California, continue travelling north for approximately 10 miles before turning right onto County Road 115. Follow County Road 115 for approximately 4 miles and the entrance road to Modoc NWR will be on the right.