Albuquerque, NM
Take I-25 north to Santa Fe.
In Santa Fe, the byway begins on I-25 heading southeast toward Las Vegas, NM.
Denver, CO
* Take I-25 south toward Pueblo.
* In Pueblo merge onto US-50 east.
* Follow US-50 until La Junta where you will join the byway.
Santa Fe, NM
* In Santa Fe, the byway begins on I-25 heading southeast toward Las Vegas, NM.
Navigating the Byway:
#Colorado Section
* The Colorado section of the Santa Fe Trail starts at the state line of Colorado and Kansas on US 50.
* Drive west on US 50 to Goff Ave in Granada, CO.
* Continue west on Goff Ave to Main St. in Lamar, CO, then continue north to US 50.
* Continue west on US 50 to Bent Ave.
* Drive south to Ambassador Thompson Blvd, then head west to E. 1st Dr.
* Make your way west to Barnes Ave, then south to W. 5th St.
* Continue west to Potter Dr. and then southwest to John F. Kennedy Memorial Hwy.
* Drive south on John F. Kennedy Memorial Hwy to the state line of Colorado and New Mexico, where the Colorado section ends.
#New Mexico Section
###CO/NM Border to Springer, NM###
* The New Mexico section of the Santa Fe Trail begins on I-25 at the New Mexico state line.
* Take I-25 south to Raton.
* In Raton, continue following I-25 south.
* Merge onto US-64 west.
* Follow US-64 south to Cimarron.
* In Cimarron, US-64 turns into Kit Carson Hwy and 10th St.
* Turn left onto NM-21 and go to Springer, where the byway branches south and east.
###Springer, NM to NM/OK Border###
* Take US-56 east to the junction with NM-453.
* Take NM-453 north to Grenville.
* In Grenville turn east onto US-64 and travel to Clayton.
* In Clayton get onto US-56 for a short journey east to the junction with NM-406.
* Turn north on NM-406 and follow the road to the NM-OK border.
###Springer, NM to Santa Fe, NM###
* Start in Springer at the junction of NM-21 and Maxwell Ave.
* Travel south along Maxwell Ave. and take on-ramp to I-25.
* Continue traveling south on I-25 through Wagon Mound.
* Travel southwest on I-25 and exit onto NM-161.
* Travel northwest on NM-161 to the Fort Union National Monument.
* Return to I-25 and travel southwest.
* Exit onto NM-161 and travel northwest through Golondrinas, past Riner Lake.
* At the junction with NM-518, the byway branches north and south.
* Travel north on NM-518 to La Cueva.
* Return south on NM-518 to the junction with NM-161 and continue south on NM-518 to Las Vegas.
* From there, get on US-85 and go through Romerville, Tecolote, and Bernal.
* In Bernal, continue on US-85 to Rowe.
* At Rowe, exit onto NM-63 and go to Pecos.
* In Pecos, take NM-50 west and merge with US-85.
* Continue on US-85 and take off-ramp to US 285.
* Exit onto NM 300/Old Las Vegas Hwy.
* Travel northwest on Old Las Vegas Hwy to Co Rd 67C.
* Continue northeast and take a left onto Old Santa Fe Trail.
* Continue north on Old Santa Fe Trail until the junction with E Alameda St. in Santa Fe where the byway ends.